Method of using foxo3a polymorphisms and haplotypes to...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2733597

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physi-cal and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovas-cular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, dia-betes, Parkinson's disease and dementia.

La présente invention porte sur des procédés et des compositions liés à l'identification et l'utilisation d'informations génétiques provenant du gène FOXO3A, qui peut être utilisé pour déterminer et augmenter la probabilité de longévité et de conservation de la fonction physique et cognitive durant le vieillissement d'un individu, et pour déterminer et diminuer la probabilité, pour un individu de développer une maladie cardiovasculaire, métabolique ou liée à l'âge, comprenant une coronaropathie, un accident cérébral vasculaire, un cancer, une maladie pulmonaire chronique, le diabète, la maladie de Parkinson et la démence.

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