A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2318382
Provided by the present invention are methods of treating a variety of diseases where enhancement of cytotoxic T cell activity has shown to be beneficial including acute viral disorders such as influenza, chronic viral disorders such as Epstein-Barr Virus (EBV), human immunodeficiency virus (HIV), herpes, hepatitis, and varicella zoster, parasitic infections such as malaria and tuberculosis, and cancer. In addition, provided by the present invention are methods of ex vivo enhancement of T cell activity from cells derived from patients with the above disorders followed by subsequent reintroduction of the modified cells into the patients.
L'invention concerne des procédés de traitement de plusieurs maladies par la stimulation de l'activité des lymphocytes T cytotoxiques. Cette stimulation s'est avérée bénéfique pour les troubles viraux aigus, tels que la grippe, les troubles viraux chroniques, dont le virus Epstein-Barr (EBV), le virus de l'immunodéficience humaine (VIH), l'herpès, l'hépatite et le virus varicelle-zona, les infections parasitaires, notamment la malaria et la tuberculose, ainsi que le cancer. L'invention concerne, en outre, des procédés de stimulation ex vivo de l'activité de lymphocytes T des lymphocytes extraits de cellules dérivées de patients souffrant des troubles précités et de réintroduction dans le patient des cellules modifiées.
Bliss Judith L.
Dorner Andrew J.
O'toole Margot
Trepicchio William L.
Genetics Institute Inc.
Genetics Institute Llc
Torys Llp
LandOfFree
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