C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/87 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2477281
A method of modulating the expression of a nucleic acid in the hepatic system of a mammal is disclosed. In addition, a method of preferentially targeting an oligonucleotide to liver cells in a mammal is disclosed. Also, a method of treating an animal having a hepatic disease or disorder associated with a protein encoded by a gene is disclosed. A composition containing an oligonucleotide is disclosed.
L'invention concerne un procédé de modification de l'expression d'un acide nucléique dans le système hépatique d'un mammifère. L'invention concerne par ailleurs un procédé de ciblage préférentiel d'un oligonucléotide vers les cellules hépatiques d'un mammifère. De plus, l'invention concerne une méthode de traitement d'un animal atteint d'une maladie hépatique ou d'un trouble associé à une protéine codée par un gène. L'invention concerne enfin une composition qui contient un oligonucléotide.
Bennett C. Frank
Cook Phillip Dan
Manoharan Muthiah
Isis Pharmaceuticals Inc.
Torys Llp
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