G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/576 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2465900
An individual's risk profile for developing a cardiovascular disorder or for experiencing a cardiovascular event is determined by 1) measuring levels of certain stress-evoked proteins including heat shock proteins (HSPs), cytokines, adhesion molecules, chemokines, and the like, or titers of the antibodies targeted to them, or 2) determining the number of seropositive responses to a group of pathogens that have been associated with the presence of atherosclerosis and/or clinical events related to atherosclerosis. The measured levels are compared with clinically derived standards that define the association of these markers with cardiovascular disease. These markers are independent of traditionally recognized risk factors.
Chez un individu, un profil de risque de développer un trouble cardio-vasculaire ou de souffrir d'un accident cardio-vasculaire est déterminé ainsi: 1) on mesure les taux de certaines protéines liées au stress, y compris des protéines de choc thermique (HSP), des cytokines, des molécules d'adhésion, des chimiokines ou similaires, ou de titres d'anticorps qui les ciblent; ou 2) déterminer le nombre de réponses séropositives d'un groupe de pathogènes associés à la présence d'athérosclérose et/ou de complications cliniques liées à l'athérosclérose. Les taux mesurés sont comparés aux standards dérivés cliniquement qui définissent l'association de ces marqueurs à une maladie cardio-vasculaire. Ces marqueurs sont indépendants des facteurs de risque reconnus traditionnellement.
Epstein Stephen E.
Zhu Juanhui
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Medstar Research Institute
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