A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61K 31/7115 (2006.01) A61K 35/76 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 39/06 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 16/00 (2006.01) C12N 1/20 (2006.01) C12N 9/16 (2006.01) C12Q 1/42 (2006.01) C12Q 1/44 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2350405
The invention is directed to a method of decreasing atheroma formation in a mammal comprising administering a pharmaceutically effective amount of PON-1 or its functional equivalent to a patient in need thereof. Also included herein are pharmaceutical compositions, and a method for diagnosing predisposition to hypercholesterolemia by assessing the level of native circulating PON-1.
L'invention se rapporte à une méthode permettant de réduire la formation d'athérome chez un mammifère et consistant à administrer une quantité pharmaceutiquement efficace de paraoxonase-1 (PON-1) ou de son équivalent fonctionnel à un patient nécessitant un tel traitement. L'invention se rapporte également à des compositions pharmaceutiques et à une méthode visant à détecter une prédisposition à l'hypercholestérolémie et consistant à évaluer le taux d'enzymes PON-1 circulants, natifs.
Borden Ladner Gervais Llp
Corporation Bayer
Talecris Biotherapeutics Inc.
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