A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/549 (2006.01) A61K 31/085 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61K 31/5383 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 13/10 (2006.01) A61P 17/14 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01)
Patent
CA 2619480
The present invention relates to the use of an effective amount of at least one potassium KvI.3 channel inhibitor or of an effective amount of at least one compound having in addition to its potassium KvI.3 channel inhibiting properties also CBx modulating properties and/or potassium K(atp) channel opening properties for the manufacture of a medicament for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of various medical conditions in subjects in need thereof . The diseases are obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, glucose metabolism - in particular, insulin resistance, hyperglycaemea and/or glucose intolerance - neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence. The compounds are a.o. 4, 5-dihydropyrazole derivatives, imidazole derivatives, diazoxide, NN414, R(+) -WIN55212-2, HU-308, Rimonaband, SR-147778.
L'invention concerne des méthodes de traitement de divers états médicaux par administration d'une dose efficace d'au moins un inhibiteur du canal du potassium Kv1.3 ou d'une dose efficace d'au moins un composé présentant outre ses propriétés d'inhibition du canal du potassium Kv1.3 des propriétés de modulation CBx et/ou des propriétés d'ouverture du canal du potassium K(atp) à des sujets nécessitant un tel traitement. L'invention concerne en outre l'utilisation d'une dose efficace d'au moins un inhibiteur du canal du potassium Kv1.3 ou d'une dose efficace d'au moins un composé présentant outre ses propriétés d'inhibition du canal du potassium Kv1.3 des propriétés de modulation CBx et/ou des propriétés d'ouverture du canal du potassium K(atp) pour la fabrication d'un médicament utilisé pour la prophylaxie, le traitement, le retard de la progression, le retard de l'apparition et/ou l'inhibition de divers états médicaux chez des sujets nécessitant un tel traitement.
Antel Jochen
Firnges Michael
Gregory Peter-Colin
Reiche Dania
Mccarthy Tetrault Llp
Solvay Pharmaceuticals Gmbh
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