Method of viral inactivation of biological fluids by...

A - Human Necessities – 61 – L

Patent

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Details

A61L 2/00 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2714281

A method of virally inactivating a biological fluid comprising : (a) a step of treating the biological fluid with a mixture of tri (n-butyl) phosphate and polyoxyethylene (4-5) p-t-octylophenol (t-Oct-C6H4- (OCH2CH2)xOH, x=5); (b) an oil extraction step, wherein the tri (n-butyl) phosphate and polyoxyethylene (4-5) p-t-octyl-phenol (t-Oct-C6H4- (OCH2CH2) xOH,x=5) containing bilogical fluid is treated with 5 to 15 volume% of soybean oil with respect to the volume of the biological fluid so as to transfer tri (n-butyl) phosphate and polyoxyethylene (4-5) p-t-octyl-phenol (t-Oct-C6H4- (0CH2CH2)xOH, x N5) from the biological fluid to the soybean oil; (c) passing the biological fluid recovered after step (b) through an activated charcoal filter, and (d) passing the biological fluid recovered after step (c) through a bacterial filter, provided that the soybean oil extraction step is the sole oil extraction step of the method.

La présente invention concerne un procédé dinactivation virale dun fluide biologique comprenant : (a) une étape de traitement du fluide biologique avec un mélange de phosphate de tri(n-butyle) et de polyoxyéthylène-(4-5)-p-t-octylphénol (t-Oct-C6H4-(OCH2CH2)xOH, x=5); (b) une étape dextraction dans lhuile, dans laquelle le fluide biologique contenant le phosphate de tri(n-butyle) et le polyoxyéthylène-(4-5)-p-t-octylphénol (t-Oct-C6H4-(OCH2CH2)xOH, x=5) est traité avec 5 à 15 % en volume dhuile de soja par rapport au volume du fluide biologique de manière à transférer le phosphate de tri(n-butyle) et le polyoxyéthylène-(4-5)-p-t-octylphénol (t-Oct-C6H4-(OCH2CH2)xOH, x=5) du fluide biologique vers lhuile de soja; (c) le passage du fluide biologique récupéré après létape (b) à travers un filtre de charbon actif, et (d) le passage du fluide biologique récupéré après létape (c) à travers un filtre bactérien, à condition que létape dextraction dans lhuile de soja soit la seule étape dextraction dans lhuile du procédé.

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