Method, reagent and kit for the detection of fecal occult blood

Details Method, reagent and kit for the detection of fecal occult blood Method, reagent and kit for the detection of fecal occult blood

G - Physics

01

N

G01N 33/72 (2006.01) C12Q 1/28 (2006.01)

Patent

CA 2171872

A fecal specimen may be tested for the presence of occult blood combining the fecal specimen with: (a) an oxidizable substrate that produces a colored product in the presence of peroxide and hemoglobin; (b) hydrogen peroxide or a peroxide source; and (c) an enhancer selected to enhance the sensitivity of the test. Suitable enhancers are monocyclic nitrogen-containing aromatic heterocyclic compounds; tertiary or quaternary ammonium compounds having a phenyl, hydroxy alkyl or esterified hydroxy alkyl attached to the nitrogen; or quinoline or a substituted derivative thereof. If hemoglobin is present in the fecal sample, the oxidizable substrate is converted to the visibly detectable, colored product.

Il est possible de rechercher la présence de sang occulte dans un échantillon de matière fécale en combinant cet échantillon avec: (a) un substrat oxydable produisant uns substance colorée en présence de peroxyde et d'hémoglobine; (b) du peroxyde d'hydrogène ou une source de peroxyde; et (c) un activateur sélectionné en fonction de son aptitude à augmenter la sensibilité du test. Les activateurs adaptés sont les composés hétérocycliques aromatiques contenant de l'azote monocyclique; les composés tertiaires ou quaternaires d'ammonium disposant d'un phényle, hydroxy alkyle ou hydroxy alkyle estérifiée lié à l'azote; ou de la quinoléine ou un dérivé substitué de la quinoléine. Si l'hémoglobine est présente dans l'échantillon de matière fécale, le substrat oxydable se convertit en substance colorée, décelable à l'oeil.

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