Method to confer cell culture replication activity to...

Details Method to confer cell culture replication activity to... Method to confer cell culture replication activity to...

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) C07H 21/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2514918

The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.

L'invention concerne des procédés de production de réplicons du VHC au moyen de séquences de codage du VHC issues de divers isolats. Les procédés selon l'invention sont fondés sur l'importance découverte de la position 470 de l'acide aminé de la NS3 dans le fait de conférer une activité de réplication de culture cellulaire à divers isolats du VHC.

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