Method to control leukocyte extravasation

Details Method to control leukocyte extravasation Method to control leukocyte extravasation

C - Chemistry, Metallurgy

07

K

195/1.112

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/05 (2006.01) C12N 5/12 (2006.01) C12N 5/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340202

Novel antibodies that recognize endothelial cell surface molecules or synovial-specific leukocyte homing receptors and block leukocyte extravasation are provided. These antibodies recognize either tissue-specific endothelial cell surface molecules or a synovial-specific leukocyte cell surface glycoprotein and block lymphocyte migration from the blood into tissues such as mucosal lymphoid organs, peripheral lymph nodes, and synovium. Also described are novel endothelial cell surface proteins involved in leukocyte extravasation, having a molecular weight of approximately 58,000 to 69,000 daltons, which express a tissue-specific determinant, as well as a synovial-specific leukocyte glycoprotein of approximately 90,000 daltons. The antibodies are used in compositions to treat individuals having a disease or inflammation-associated pathology in which leukocyte extravasation plays a role.

574461

Affiliated with

Also associated with

Rating

Method to control leukocyte extravasation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method to control leukocyte extravasation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method to control leukocyte extravasation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1282191