Method to detect bone and other connective tissue disorders...

Details Method to detect bone and other connective tissue disorders... Method to detect bone and other connective tissue disorders...

G - Physics

01

N

G01N 33/68 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2069611

The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen- derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.

On décrit des méthodes d'évaluation du tissu conjonctif, surtout des os, du métabolisme des malades, ou permettant de contrôler les traitements, ladite méthode consistant à déterminer les taux de liaisons croisées dérivées du collagène et présentes dans les fluides biologiques, surtout l'urine. Ladite méthode peut être améliorée en mesurant simultanément les taux d'un indicateur de formation osseuse dans les fluides biologiques d'un même individu, et en déterminant les différences entre le marqueur de dégradation et l'indicateur de formation. On décrit également des anticorps qui sont spécifiquement immunoréactifs vis-à-vis des formes de liaisons croisées qui sont librement présentes dans les fluides biologiques.

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