Method to detect dopamine receptors in the functional d2high...

Details Method to detect dopamine receptors in the functional d2high... Method to detect dopamine receptors in the functional d2high...

A - Human Necessities

61

K

A61K 51/00 (2006.01)

Patent

CA 2628298

This application describes a method for identifying dopamine supersensitivity using radioactive (+)PHNO. The method involves determining the specific binding of radioactive (+)PHNO is the subject~s brain. An increase in the specific binding of radioactive (+)PHNO in the subject compared to a control indicates that the subject is in a state of dopamine supersensitivity. The extent of dopamine supersensitivity can be used to assess, treat and/or follow the progress of any dopamine-related disorder.

La présente demande concerne une méthode permettant de détecter une hypersensibilité à la dopamine à l'aide de (+)PHNO radioactive. Cette méthode consiste à déterminer une fixation spécifique de la (+)PHNO radioactive dans le cerveau du patient. Une augmentation de la fixation spécifique de la (+)PHNO radioactive chez le patient par rapport à un témoin indique que le patient est dans un état d'hypersensibilité à la dopamine. Le niveau d'hypersensibilité à la dopamine peut être utilisé pour évaluer, pour traiter et/ou pour suivre l'évolution d'un trouble lié à la dopamine.

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