Method to detect polymorphism in the s182 gene

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2235611

A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.

L'invention concerne une méthode de détection de polymorphismes dans le gène S182, qui consiste à détecter les mutations dans ledit gène au moyen d'amorces pour PCR non appariées et sélectionnées, comprenant des séquences dérivées de séquences introniques du gène S182. Une méthode d'identification d'un individu susceptible de contracter de manière tardive la maladie d'Alzheimer est également décrite.

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