Method to determine transcriptional regulation pathways in...

G - Physics – 06 – F

Patent

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G06F 19/00 (2006.01)

Patent

CA 2651929

The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.

L'invention concerne des procédés et des systèmes informatiques permettant d'identifier des rapports régulatoires entre des polypeptides régulateurs exprimés et des cibles des activités régulatoires de ces polypeptides régulateurs. L'invention concerne plus précisément un nouveau procédé permettant d'identifier les interactions entre des espèces biochimiques dans une cellule. Certains modes de réalisation concernent des procédés informatiques permettant d'identifier une interaction régulatoire entre un facteur de transcription et une cible génétique du facteur de transcription ou entre un facteur de transcription et un ensemble de cibles génétiques du facteur de transcription.

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