Method to distinguish prostate cancer from benign prostatic...

Details Method to distinguish prostate cancer from benign prostatic... Method to distinguish prostate cancer from benign prostatic...

G - Physics

01

N

G01N 33/574 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2370290

A method of distinguishing prostate cancer from benign prostatic hyperplasia (BPH) is provided. The mathematical combination or ratio of proPSA and BPSA serum or tissue markers may be used for distinguishing benign prostatic hyperplasia (BPH) from prostate cancer. It is the discovery of the present invention that BPSA is preferentially elevated in transition zone prostate tissue whereas pPSA is elevated in the peripheral zone of prostate tissue. A kit for aiding in distinguishing BPH from prostate cancer is also provided.

L'invention concerne un procédé permettant de distinguer le cancer de la prostate de l'hyperplasie bénigne de la prostate (BPH). La combinaison ou le rapport mathématique de marqueurs de sérum ou de tissu de proPSA et BPSA peut servir à distinguer l'hyperplasie bénigne de la prostate (BPH) du cancer de la prostate. BPSA est, de préférence, élevé dans le tissu prostatique de la zone de transition, et pPSA dans la zone périphérique dudit tissu. L'invention concerne en outre une trousse qui permet de distinguer la BPH du cancer de la prostate.

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