Method to enhance healing of sternum after sternotomy

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61K 9/16 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2385498

There are disclosed a method to enhance sternal treatment after sternotomy with or without removal of at least onE of thoracic arteries which comprises applying an agent for the treatment of sternum after sternotomy to or at around the sternum, wherein the agent comprises at least one selected from the group consisting of an angiogenetic factor, an osteogenetic factor and their analogues such as bFGF, aFGF, TGF .beta., VEGF, HGF, BMP, PDGF, TGF .alpha., other cytokines or gene as an effective ingredient and an agent to be used for the method; an agent to enhance healing of or treating sternum after sternotomy comprising the same and use of the agent.

Cette invention se rapporte à un procédé visant à favoriser le traitement du sternum après une sternotomie, avec ou sans retrait d'au moins l'une des artères thoraciques, ce procédé consistant à appliquer un agent de traitement du sternum après sternotomie sur ou autour du sternum, cet agent comprenant au moins un élément choisi dans le groupe constitué par un facteur angiogénétique, un facteur ostéogénétique et leurs analogues, tels que bFGF, aFGF, TGF .beta., VEGF, HGF, BMP, PDGF, TGF .alpha., d'autres cytokines ou un gène comme principe actif, et un agent à utiliser dans ce procédé; ainsi qu'à un agent visant à favoriser la cicatrisation ou le traitement du sternum après une sternotomie et contenant cet élément, ainsi qu'à l'utilisation de cet agent.

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