Method to identify polypeptide toll-like receptor (tlr) ligands

Details Method to identify polypeptide toll-like receptor (tlr) ligands Method to identify polypeptide toll-like receptor (tlr) ligands

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01)

Patent

CA 2596248

The present invention provides novel methods to identify polypeptide ligands for Toll-like Receptors (TLRs), such as TLR2, TLR4 and TLR5. The method involves the use of phage display technology in an iterative biopanning procedure. The invention also provides polypeptide TLR ligands identified by the methods of the invention. In preferred embodiments, the polypeptide TLR ligands so identified modulate TLR signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising a polypeptide TLR ligand identified by the methods of the invention and an antigen. The invention also provides methods of modulating TLR signaling using the polypeptide TLR ligands and vaccines of the invention.

L'invention concerne de nouveaux procédés pour identifier des ligands polypeptidiques de récepteurs de type Toll (TLR), tels que les TLR2, TLR4 et TLR5. Un procédé consiste à appliquer la méthode d'expression phagique dans un processus de biopanning itératif. La présente invention porte également sur des ligands polypeptidiques TLR identifiés selon ces procédés. Dans des modes de réalisation préférés, les ligands polypeptidiques TLR ainsi identifiés modulent la signalisation TLR et régulent par conséquent la réponse immunitaire innée. La présente invention porte aussi sur des vaccins contenant un ligand polypeptidique TLR identifié selon lesdits procédés et un antigène, ainsi que sur des procédés pour moduler la signalisation TLR au moyen de ligands polypeptidiques TLR et de vaccins de l'invention.

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