Method to identify transcriptional modulators

Details Method to identify transcriptional modulators Method to identify transcriptional modulators

G - Physics

01

N

G01N 33/68 (2006.01) C12N 5/10 (2006.01) C12N 9/90 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01) G01N 3/50 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2313252

Novel synthetic transcriptional modulators having at least one selected ligand linked to at least one transcriptional modulating portion are described. The transcriptional modulators of the present invention can include a ligand linked to a chemical moiety. These transcriptional modulators can be used to selectively control gene expression and to identify components of the transcriptional machinery.

L'invention porte sur de nouveaux modulateurs de transcription de synthèse présentant au moins un ligand sélectionné lié à au moins une portion modulant la transcription. Lesdits modulateurs, qui peuvent comporter un ligand lié à un fragment chimique, peuvent servir à réguler sélectivement l'expression de gènes et à identifier certains composants du mécanisme de transcription.

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