A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2230086
Methods for improving the cellular uptake of protease inhibitors (e.g., HIV protease inhibitor), alone or in the presence of one or more additional therapeutic agents, in protease inhibitor-based therapies, involving administration of one or more AAG-binding compounds, such as macrolide or lincosamide antibiotics, which have sufficient binding affinity for AAG to competitively bind AAG in the presence of the protease inhibitor.
L'invention porte sur des procédés améliorant l'absorption cellulaire d'inhibiteurs de protéases (par exemple des inhibiteurs des protéases du VIH), utilisés seuls ou en présence d'un ou plusieurs agents thérapeutiques additionnels, pour des thérapies à base d'inhibiteurs de protéases, qui consiste à administrer un ou plusieurs composés fixant l'AAG tels que des antibiotiques du type macrolide ou lincosamide et présentant une affinité de fixation avec l'AAG suffisamment forte pour se lier de manière concurrentielle à l'AAG en présence de l'inhibiteur de protéase.
Schinazi Raymond F.
Sommadossi Jean-Pierre
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schinazi Raymond F.
Uab Research Foundation
University Of Alabama At Birmingham
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