Method to induce the th1 immune response

Details Method to induce the th1 immune response Method to induce the th1 immune response

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 37/08 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2408688

The present invention relates to a method to induce the CD4+ Th1 immune response, eventually combined with a repression of the Th2 mediated activities, comprising the administration of an IgG isotype antibody which is not an IgG1 isotype antibody. Preferentially said antibody is an IgG2a and/or IgG2b isotype anti-allergen antibody. The shift from a Th2 response towards a mixed Th1/Th2 response is particularly useful in the treatment of diseases such as asthma.Because the method described corrects the immuno-pathological cause of the disease, this is the polarised Th2 response against allergen, rather than its consequences, a sustained cure from asthma can be achieved instead of a transient reduction of symptoms.

L'invention concerne un procédé permettant d'induire une résonse immunitaire de la Th1 de CD4+, éventuellement en combinaison avec une répression des activités induites par la Th2. Ce procédé comprend le fait d'administrer un anticorps isotype IgG1. Ledit anticorps est de préférence un anticorps anti-allergène isotype IgG2a et/ou IgG2b. Le passage d'une réponse de la Th2 à une réponse mixte de la Th1/Th2 est particulièrement utile dans le traitement d'affections telles que l'asthme. Comme le procédé décrit corrige la cause immuno-pathologique de l'affection, c'est la réponse polarisée de la Th2 vis-à-vis de l'allergène plutôt que ses conséquences, un traitement soutenu de l'asthme peut être obtenu plutôt qu'une diminution transitoire des symptômes.

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