Method to inhibit cell growth using oligonucleotides

Details Method to inhibit cell growth using oligonucleotides Method to inhibit cell growth using oligonucleotides

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) A61K 31/07 (2006.01) A61K 31/7088 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2481372

Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g.,human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.

L'invention concerne des procédés de traitement de troubles hyperprolifératifs, notamment du cancer, par administration au mammifère atteint (par exemple, un être humain) d'une dose efficace d'une composition comprenant des oligonucléotides pTT ou d'une composition comprenant un ou plusieurs oligonucléotides qui partagent au moins 50 % d'identité de séquence nucléotidique avec la répétition de dépassement télomérique humain. L'invention concerne également des procédés de traitement ou de prévention de troubles hyperprolifératifs ou d'états précancéreux affectant les cellules épithéliales, de type psoriasis, dermatite atopique, ou dermatoses hyperprolifératives ou réagissant aux UV, de maladies hyperprolifératives d'autre épithélium et des procédés de réduction du photovieillissement, du stress oxydatif, ou des procédés prophylactiques permettant de lutter contre la probabilité du développement du cancer de la peau et de réduire celle-ci.

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