Method to obtain microparticles containing a h+, k+ -atp-ase...

Details Method to obtain microparticles containing a h+, k+ -atp-ase... Method to obtain microparticles containing a h+, k+ -atp-ase...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2440163

A method for the preparation of homogenous microparticles containing a H+, K+ - ATP-ase inhibitor using a fluid-bed granulation technique. The microparticles that have a desired size distribution are selected. At least 80% of the microparticle based on its dry weight content is the acid labile H+, K+ -ATP- ase inhibitor.

L'invention concerne un procédé de préparation de microparticules homogènes contenant un inhibiteur de H?+¿, K?+¿-ATP-ase au moyen d'une technique de granulation en lit fluidisé. On choisit les microparticules qui présentent une distribution granulométrique voulue. Au moins 80 % des microparticules, sur la base de leur teneur en poids en extrait sec, sont constituées par l'inhibiteur de H?+¿, K?+¿ -ATP-ase labile acide.

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