A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/335 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2398840
The use of estramustine phosphate and its metabolites estramustine and estromustine allow to potentiate the therapeutic efficacy of taxanes by both improving their pharmacokinetic and pharmacodynamic profile through the inhibition of (CYP)2C8 and (CYP)3A4 enzymes, both responsible for the metabolism of the taxanes; formulations of estramustine phosphate and metabolites, combinations of these latter with taxanes and therapeutic methods of treatment comprising them as a combined therapy are also disclosed.
L'invention concerne l'utilisation de l'estramustine phosphate et de ses métabolites estramustine et estromustine afin de potentialiser l'efficacité thérapeutique des taxanes en augmentant leur profil pharmacocinétique et pharmacodynamique par l'inhibition des enzymes (CYP)2C8 et (CYP)3A4, tous deux responsables du métabolisme des taxanes. L'invention concerne également des formulations d'estramustine phosphate et de métabolites, des combinaisons de ces derniers avec des taxanes et des méthodes de traitement contenant ces éléments de manière à constituer une thérapie combinée.
Ings M. J. Robert
Monshouwer Marius
Rocchetti Maurizio
Pharmacia & Italia S.p.a.
Smart & Biggar
LandOfFree
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