Method to produce inactivated w/o emulsion adjuvanted vaccines

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 9/107 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01)

Patent

CA 2352563

The present invention is directed to a method to prepare an inactivated w/o emulsion adjuvated vaccine, wherein an aqueous solution comprising one or more inactivated angigens is mixed under mild conditions with a ready-made w/o emulsion. Preferably the vaccine is prepared just prior to vaccination. The aqueous solution and w/o emulsion are stirred or shaken by mechanical means or by hand. The present invention also relates to a kit of parts for use in a method according to the invention.

La présente invention concerne une méthode de préparation d'un vaccin inactivé associé à une émulsion eau dans huile adjuvante. Cette méthode consiste à mélanger une solution aqueuse comprenant un ou plusieurs antigènes inactivés dans des conditions non agressives avec une émulsion eau dans huile prête à l'emploi. Le vaccin est préparé de préférence juste avant la vaccination. Cette solution aqueuse et l'émulsion eau dans huile sont brassées ou agitées mécaniquement ou manuellement. La présente invention concerne aussi un coffret d'éléments utilisable dans une méthode se rapportant à l'invention.

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