Method to produce modified plants with altered...

Details Method to produce modified plants with altered... Method to produce modified plants with altered...

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2704108

Provided is a novel method to produce a plant cell or plant having an altered N-glycosylation pattern resulting, in particular, in a low level of .beta.-1,2-xylose residues and core .alpha.-1,3- fucose residues on protein-bound N -glycans. Said plant cell or plant is of particular interest for producing therapeutic glycoproteins with a low, or not detectable, level of .beta.-1,2-xylose and .alpha.-1,3-fucose residues. Also provided are novel .alpha.-1,3-fucosyltransferase nucleotide sequences and uses thereof.

Cette invention a trait à un nouveau procédé de production d'une cellule végétale ou d'une plante à schéma de N-glycosylation modifié donnant lieu, en particulier, à un taux faible de résidus de ß-1,2-xylose et de résidus de noyau a-1,3-fucose sur des N-glycanes liées à des protéines. Ladite cellule végétale ou ladite plante présente un intérêt particulier dans la production de glycoprotéines thérapeutiques à taux faible, voire indétectable, de ß-1,2-xylose et d'a-1,3-fucose. L'invention concerne également de nouvelles séquences nucléotidiques d'a-1,3-fucosyltransférase et leurs utilisations.

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