Method to produce powders for pulmonary or nasal administration

Details Method to produce powders for pulmonary or nasal administration Method to produce powders for pulmonary or nasal administration

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/46 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2382216

A pharmaceutical formulation comprises a mixture of two or more drugs optionally together with one or more excipients, the mixture being formed by the steps of: co-crystallisation or co-precipitation of the drugs followed by micronisation or milling to produce a uniform powder having a particle size and other properties suitable for formulation for pulmonary or nasal administration.

L'invention concerne une formulation pharmaceutique comprenant un mélange de deux médicaments éventuellement associés à un ou plusieurs excipients, ledit mélange étant obtenu par: co-cristallisation ou co-précipitation des médicaments, puis par micronisation ou broyage, de manière à produire une poudre uniforme ayant une granulométrie et autres propriétés appropriées pour constituer une formulation destinée à être administrée par voie pulmonaire ou nasale.

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