Method to reduce intraocular pressure without causing miosis

A - Human Necessities – 61 – K

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A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2052438

9792P/5902A 18167 TITLE OF THE INVENTION A METHOD TO REDUCE INTRAOCULAR PRESSURE WITHOUT CAUSING MIOSIS ABSTRACT OF THE DISCLOSURE Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a mammal reduces intraocular pressure without the concommitant miotic effect that normally occurs with administration of a cholinomimetic agent alone.

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