Method to separate the isomers of a crown compound and...

C - Chemistry – Metallurgy – 07 – D

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260/373.1

C07D 323/00 (2006.01) B01J 19/00 (2006.01)

Patent

CA 2031752

ABSTRACT OF THE DISCLOSURE The invention concerns a method for separating the isomers of a crown compound and making it possible to recover in particular the pure cis-syn-cis isomer from DCH 18C6. This method includes the following stages : a) dissolving in an organic solvent a mixture of the isomers of said crown compound including the cis- anti-cis isomer and the cis-syn-cis isomer, b) adding uranyl nitrate to the solution obtained in stage a) is sufficient quantities so that virtually all the isomers, except the cis-syn cis isomer, are precipitated in the form of complexes with the uranyl nitrate, c) separating the formed precipitate, and d) recovering the pure cis-syn-cis isomer from the solution, and e) recovering the pure cis-anti-cis isomer from the precipitate. Fig. 1 B 10143 MDT

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