Method to treat the side effects associated with non...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/74 (2006.01) A61K 31/19 (2006.01) A61K 31/205 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2537769

The present invention relates to the use of a microorganism and/or a metabolite thereof to at least increase the amount of a COX-1 mRNA in a cell. The present invention further relates to the use of a microorganism and/or a metabolite thereof in the manufacture of a medicament to treat the side effects associated with nonsteroidal anti~inflammatory drugs (NSAIDs). The present invention further relates to a pharmaceutical preparation comprising in combination a nonsteroidal anti~inflammatory drug (NSAIDs) and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The present invention yet further relates to a pharmaceutical preparation comprising in combination betaine or a pharmaceutically acceptable salt thereof and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The microorganism may suitably be a bacterium, preferably from the genus Bifidobacterium.

L'invention concerne l'utilisation d'un micro-organisme et/ou d'un de ses métabolites pour au moins augmenter la quantité d'ARNm COX-1 dans une cellule, l'utilisation d'un micro-organisme et/ou d'un de ses métabolites pour produire un médicament pour soigner les effets secondaires associés aux médicaments anti-inflammatoires non-stéroidaux (NSAIDs), une préparation pharmaceutique qui comprend une combinaison d'un médicament anti-inflammatoire non-stéroidal (NSAID) et d'un micro-organisme et/ou d'un de ses mécanismes susceptible d'au moins augmenter la quantité d'ARNm COX-1 dans une cellule, une préparation pharmaceutique qui comprend une combinaison de bétaïne ou d'un de ses sels pharmaceutiquement acceptables et d'un micro-organisme et/ou d'un de ses métabolites susceptible d'au moins augmenter la quantité d'ARNm COX-1 dans une cellule. Le micro-organisme peut être une bactérie appropriée, de préférence du genre Bifidobacterium.

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