Method using oxygen removal for extending the useful...

Details Method using oxygen removal for extending the useful... Method using oxygen removal for extending the useful...

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2223130

A cost-effective, 4 °C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 °C for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

Procédé incluant l'élimination de l'oxygène en vue de prolonger la durée de vie utile des globules rouges réfrigérés. Un processus de stockage à 4 DEG C, réduisant les coûts, permet de préserver la qualité des globules rouges et de prolonger leur durée de vie in vivo après transfusion. On parvient à conserver les taux d'adrénosine-triphosphate et à réduire l'hémolyse ainsi que la formation de vésicules membraneuses des globules rouges stockés à 4 DEG C sur des périodes prolongées en éliminant l'oxygène de ceux-ci pendant leur stockage. Les taux d'adrénosine-triphosphate des globules rouges stockés sont augmentés dans certains échantillons par l'addition de phosphate d'ammonium.

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