Methode of manufacturing glimepiride and the respective...

Details Methode of manufacturing glimepiride and the respective... Methode of manufacturing glimepiride and the respective...

C - Chemistry, Metallurgy

07

D

C07D 207/38 (2006.01) C07C 211/35 (2006.01)

Patent

CA 2515520

A method of manufacturing glimepiride of formula I wherein trans-4- methylcyclohexylamine pivalate of formula (VII) is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-lH-pyrrol-l yl)carbonyl]amino)ethyl)phenyl]-sulfonyl carbamate of general formula (IV) wherein R is a C1-C5 alkyl, giving glimepiride of formula I. trans-4- Methylcyclohexylamine pivalate of formula (VII).

L'invention concerne une méthode de fabrication de glimepiride de formule (I). Dans cette formule, le pivalate de trans-4-méthylcyclohexylamine de formule (VII) réagit, soit directement, ou après conversion en trans-4-méthylcyclohexylamine ou en un autre de ses sels, avec un carbamate d'alkyle [4-(2-{[(3-éthyl-4-méthyl-2-oxo-2,5-dihydro-lH-pyrrol-l yl)carbonyl]amino)éthyl)phényl]-sulfonyle de formule (IV), R désignant un alkyle C¿1?-C¿5?, pour donner du glimepiride de formule (I).

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