G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2750076
The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient, assaying the amount of gelsolin present in said sample, comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject,, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient Other markers are C1 protease inhibitor and ceruloplasmin Both blood samples and tissue samples have been investigated
La présente invention porte sur un procédé d'aide au diagnostic ou au suivi du pronostic de la maladie d'Alzheimer chez un sujet, ledit procédé consistant à : fournir un échantillon de sang obtenu chez ledit patient; doser la quantité de gelsoline présente dans ledit échantillon; comparer la quantité de gelsoline présente dans ledit échantillon à une quantité de référence de gelsoline présente dans un échantillon provenant d'un sujet sain, la détection dans l'échantillon provenant dudit patient d'un niveau de gelsoline inférieur au niveau de gelsoline dans l'échantillon de référence indiquant une probabilité accrue de maladie d'Alzheimer chez ledit patient.
Byers Helen Louise
Campbell James
Guentert Andreas Christian
Lovestone Simon Harold
O'brien Darragh Patrick William
Borden Ladner Gervais Llp
Electrophoretics Limited
King's College London
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