Methods, agents, and compound screening assays for inducing...

Details Methods, agents, and compound screening assays for inducing... Methods, agents, and compound screening assays for inducing...

G - Physics

01

N

G01N 33/566 (2006.01) A61P 19/10 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2562833

The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound- polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for thein vitro production of bone tissue.

L'invention concerne des procédés, des agents et des analyses de criblage de composés permettant d'induire une différenciation de cellules mammaliennes non différenciées en ostéoblastes. Selon le procédé de l'invention, on met en contact un composé avec un polypeptide comprenant une séquence d'acides aminés choisie dans le groupe composé des SEQ ID No: 194-309; et on mesure une propriété du polypeptide-composé liée à la différenciation desdites cellules. L'invention se rapporte également à une composition pharmaceutique permettant de favoriser la formation osseuse, et à l'utilisation de cette dernière dans le traitement et/ou la prévention d'une maladie impliquant une réduction systémique ou locale de la densité osseuse moyenne chez un sujet. L'invention porte en outre sur un procédé permettant la production de tissu osseux in vitro.

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