Methods and adjuvants for stimulating mucosal immunity

Details Methods and adjuvants for stimulating mucosal immunity Methods and adjuvants for stimulating mucosal immunity

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 39/39 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2346452

The invention relates to methods for inducing mucosal immunity to an antigen and provides oligonucleotide adjuvants effective in stimulating such immunity against antigens. The adjuvants provided by the invention have little toxicity, are relatively simple to manufacture as compared to cholera toxin and other mucosal adjuvants, and possess the additional advantages of biasing the host immune response toward the Th1 phenotype.

L'invention concerne des procédés permettant d'induire une immunité des muqueuses à un antigène. L'invention a aussi pour objet des adjuvants d'oligonucléotides permettant de stimuler avec efficacité cette immunité contre les antigènes. Les adjuvants selon l'invention présentent une faible toxicité, sont relativement simples à fabriquer par rapport à la toxine du choléra et d'autres adjuvants des muqueuses, et ont l'avantage de polariser la réponse immunitaire de l'hôte vers le phénotype Th1.

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