Methods and agents for inhibiting dynamin-dependent endocytosis

Details Methods and agents for inhibiting dynamin-dependent endocytosis Methods and agents for inhibiting dynamin-dependent endocytosis

A - Human Necessities

61

K

A61K 31/275 (2006.01) A61P 25/00 (2006.01) C07C 255/34 (2006.01) C07C 255/40 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2556801

There are disclosed methods for inhibiting dynamin-dependent endocytosis in cells comprising treating the cells with an effective amount of a compound of formula (I), or a dimeric tyrphostin, physiologically acceptable salt, or prodrug thereof. Compounds useful in the methods described are also provided. The inhibition of dynamin-dependent endocytosis of cells is applicable to the treatment of epilepsy and neurological disorders and conditions.

Cette invention concerne des procédés servant à inhiber l'endocytose dépendant de la dynamine et consistant à cet effet à traiter ces cellules avec une quantité efficace d'un composé représenté par la formule (I), ou d'une tyrphostine dimère, d'un sel physiologiquement acceptable ou d'un promédicament de ce composé. Les composés utiles dans ce procédé sont également présentés. L'inhibition de l'endocytose dépendant de la dynamine est applicable au traitement de l'épilepsie et des troubles et états neurologiques.

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