G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) A61K 31/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2692072
The application is based on the observation that tumor stem cell (TSC) replication involves a replicative intermediate configuration wherein a substantial fraction of the TSC genome is present as single-stranded DNA (ssDNA) when bell-shaped nuclei commence separation into two nuclei. During this replicative intermediate configuration large amounts of ssDNA are thus present in the nuclei of cells which the applicant proposes as target for anti-tumor therapy. A method of screening for anti-tumorigenic agents targeting ssDNA and use of such agents in therapy is claimed.
L'invention concerne des méthodes d'identification d'agents destinés à l'inhibition spécifique de la croissance/prolifération de cellules souches tumorales ou à leur destruction complète, quasiment sans danger pour les cellules souches saines ou de maintien dans leur environnement immédiat. L'invention concerne en outre les applications thérapeutiques desdits agents.
Gostjeva Elena V.
Thilly William G.
Borden Ladner Gervais Llp
Massachusetts Institute Of Technology
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