Methods and agents for modulating an immune response

Details Methods and agents for modulating an immune response Methods and agents for modulating an immune response

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2642708

This invention is directed to the targeting of proteins or peptides of interest to an autophagosome, for their presentation on a major histocompatibility complex (MHC) class II molecule and methods of use thereof. Nucleic acids, vectors comprising the same, and compositions for targeting proteins or peptides of interest to an autophagosome, for their presentation on a major histocompatibility complex (MHC) class II molecule are disclosed as are methods of use thereof for stimulating or enhancing immune responses in a subject.

La présente invention concerne le ciblage de protéines ou de peptides d'intérêt sur un autophagosome en vue de leur présentation sur une molécule du complexe majeur d'histocompatibilité (CMH) de classe II, ainsi que des procédés pour les utiliser. Elle concerne également des acides nucléiques, des vecteurs les comprenant et des compositions destinées au ciblage de protéines ou de peptides d'intérêt sur un autophagosome en vue de leur présentation sur une molécule du complexe majeur d'histocompatibilité (CMH) de classe II, ainsi que des procédés pour les utiliser afin de stimuler ou d'activer des réponses immunitaires chez un sujet.

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