C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 2/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C07K 16/00 (2006.01) C07K 16/44 (2006.01) C12N 5/06 (2006.01) C12N 5/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2135748
2135748 9323081 PCTABS00028 A method of enhancing antigen presentation is disclosed, wherein an antigen is modified by reaction with AGEs or a compound which forms AGEs. The AGEs are formed on or attached to the antigen, at a site which either activates an epitope containing the site of AGE attachment or formation, or which activates a different site in the antigen, a so-called "silent" epitope. This may comprise an actual activation process, a shift in the dominance to a different epitope by reducing recognition of the epitope upon which the AGEs are found or another mechanism. Also included are the antibodies which recognize these epitopes, methods of treatment and use, assay techniques and kits for performing such methods.
Bucala Richard J.
Cerami Anthony
Skolnik Edward Y.
Vlassara Helen
Swabey Ogilvy Renault
The Rockefeller University
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