Methods and agents for the diagnosis and treatment of...

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G01N 33/574 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2718869

The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.

La présente invention concerne des procédés de diagnostic et des procédés de traitement dun carcinome hépatocellulaire chez un sujet. Linvention concerne également des antagonistes de protéines PLVAP, tels que des anticorps qui se lient spécifiquement aux protéines PLVAP, ainsi que des compositions et des kits qui comprennent des antagonistes de protéines PLVAP. Linvention concerne également des anticorps humanisés qui se lient spécifiquement à la protéine PLVAP.

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