Methods and apparatus for centrifugal liquid chromatography

Details Methods and apparatus for centrifugal liquid chromatography Methods and apparatus for centrifugal liquid chromatography

B - Operations, Transporting

01

D

B01D 15/08 (2006.01) G01N 30/00 (2006.01)

Patent

CA 2755247

Apparatus and methods related to centrifugal liquid chromatography are described. An angular velocity can be simultaneously imparted to a large number of chromatographic enclosures. Via centrifugal forces, a mobile phase fluid including a sample can be driven through a stationary phase within the chromatographic enclosure to perform a chromatographic separation process on components of the sample. The use of centrifugation as a driving force can allow significantly smaller stationary phase particles to be employed as compared to high performance liquid chromatography (HPLC). Further, for an equivalent chromatographic separation process, the use of centrifugation can provide much greater separation efficiencies than HPLC.

L'invention concerne un appareil et des procédés associés à la chromatographie liquide par centrifugation. Une vitesse angulaire peut être conférée simultanément à un grand nombre d'enceintes chromatographiques. Sous l'action des forces centrifuges, une phase fluide mobile contenant un échantillon peut être dirigée à travers une phase stationnaire se trouvant à l'intérieur de l'enceinte chromatographique pour effectuer un processus de séparation chromatographique sur les composants de l'échantillon. L'utilisation de la centrifugation comme force motrice permet d'utiliser beaucoup moins de particules de phase stationnaire, en comparaison avec la chromatographie liquide haute performance (CLHP). En outre, pour un processus de séparation chromatographique équivalent, l'utilisation de la centrifugation peut donner des efficacités de séparation biens meilleures qu'en CLHP.

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