Methods and apparatus for creating particle derivatives of...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01)

Patent

CA 2531227

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

L'invention concerne des systèmes, un appareil et des procédés de création de dérivés d'au moins une forme de lipoprotéine de haute densité HDL, sans modifier sensiblement la lipoprotéine de basse densité LDL. Ces dérivés de HDL sont des particules à taux de lipides réduit, notamment à taux de cholestérol particulièrement réduit. Ces particules possèdent la capacité de fixer le cholestérol et sont administrées à un patient pour augmenter l'efflux du cholestérol cellulaire et réduire les taux de cholestérol dans des cellules, des tissus, des organes et des vaisseaux sanguins. Le procédé de l'invention est utile pour le traitement de maladies vasculaires athérogènes et peut être combiné à d'autres thérapies utilisant des statines, des inhibiteurs de l'absorption du cholestérol, de la niacine, des anti-inflammatoires, l'exercice et des restrictions alimentaires.

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