Methods and apparatus for detecting the rejection of...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61B 1/018 (2006.01) A61B 10/00 (2006.01) A61B 17/28 (2006.01) A61B 19/00 (2006.01)

Patent

CA 2283949

Methods and apparatus for detecting the possible rejection of a transplanted tissue by a host. The transplanted tissue is subjected to illumination with light to induce fluorescence. The light can be ultraviolet light, visible light or infrared light, which can be used alone or in any combination, which means one, two or three forms of light may be used together. The induced fluorescence is collected and analyzed, then compared with fluorescence that is obtained using the same procedure for a known, healthy tissue that is the same type of tissue as the transplanted tissue. Also provided are methods and apparatus related to the determination of probe orientation and the need for biopsy.

L'invention concerne des procédés et dispositif de détection d'un possible rejet, par un hôte, d'un tissu greffé. On soumet ce tissu greffé à un rayonnement, à l'aide d'une lumière, afin d'induire une fluorescence, la lumière pouvant être une lumière ultraviolette, une lumière visible ou une lumière infrarouge, et on peut utiliser cette lumière seule ou combinée, ce qui signifie que l'on peut utiliser ensemble deux ou trois formes de lumière. Puis on recueille et on analyse la fluorescence induite, et on la compare à une fluorescence obtenue à l'aide de la même procédure pour un tissu connu et sain, du même type que le tissu greffé. L'invention concerne également des procédés et dispositif se rapportant à la détermination de l'orientation de la sonde et à la nécessité d'une biopsie.

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