Methods and apparatus for making liposomes containing...

Details Methods and apparatus for making liposomes containing... Methods and apparatus for making liposomes containing...

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2205500

The present application features methods and apparatus for making liposomes containing hydrophobic drugs, with critical, supercritical or near critical fluids. The methods and apparatus combine a phospholipid, a drug, and an aqueous phase, or multilamellar vesicles, with a critical, supercritical or near critical fluid. Upon a reduction in pressure, liposomes are formed.

La présente invention concerne des procédés et des dispositifs de confection de liposome contenant des médicaments hydrophobes, avec des fluides critiques, supercritiques ou quasicritiques. Ces procédés et ces dispositifs combinent avec un fluide critique, supercritique ou quasicritique, un phospholipide, un médicament et une phase aqueuse ou des vésicules multilamellaires. Les liposomes se forment par réduction de la pression.

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