Methods and apparatus for multi-vessel renal neuromodulation

A - Human Necessities – 61 – N

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A61N 1/18 (2006.01) A61B 18/12 (2006.01) A61N 1/36 (2006.01)

Patent

CA 2655099

Methods and apparatus are provided for multi-vessel neurornodulation, e.g., via a pulsed electric field. Such multi-vessel neurornodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up- regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.

La présente invention concerne des procédés et un appareil de neuromodulation multicuve, par exemple, par un champ électrique à impulsions. Une telle neuromodulation multicuve est susceptible de produire une électroporation ou une électrofusion irréversibles, une nécrose et/ou une apoptose, une modification de l'expression d'un gène, une atténuation ou un blocage d'un potentiel d'action, des changements de la régulation à la hausse d'une cytokine et d'autres conditions dans des fibres neurales cibles. Dans certains modes de réalisation, la neuromodulation multicuve est appliquée à des fibres neurales qui contribuent à la fonction rénale. Dans certains modes de réalisation, une telle neuromodulation multicuve est réalisée bilatéralement.

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