Methods and apparatus for particle precipitation and coating...

B - Operations – Transporting – 01 – D

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B01D 12/00 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01) B01J 2/04 (2006.01) B01J 19/10 (2006.01) B05D 1/02 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2247900

Improved method and apparatus (110) for particle precipitation and coating using near- or supercritical fluid conditions. A fluid dispersion (128) having a continuous phase dispersant and at least one precipitable substance therein is contacted with a supercritical fluid (SCF) antisolvent (126) so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets. The enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 microns. In coating processes, a turbulent fluidized flow of core particles is created using SCF antisolvent in an enclosed zone. The core particles are contacted therein at or near supercritical conditions by fluid dispersion containing a dispersant and together with a precipitable substance. The antisolvent depletes the dispersant and the substance is precipitated onto fluidized particles.

Cette invention se rapporte à un procédé et à un appareil améliorés (110) pour la précipitation et l'enrobage de particules au moyen d'un fluide dans des conditions quasi-critiques ou supercritiques. A cet effet, une dispersion fluide (128), contenant un dispersant en phase continue et au moins une substance précipitable, est mise en contact avec un fluide supercritique (FSC) servant d'antisolvant (126), afin de générer des ondes soniques d'antisolvant haute fréquence focalisées, ce qui rompt la dispersion en gouttelettes extrêmement petites. Les vitesses de transfert de masse accrues entre les gouttelettes et l'antisolvant entraînent la précipitation de particules très petites de l'ordre de 0,1 à 10 microns. Dans des procédés d'enrobage, un flux fluidisé turbulent de particules noyaux est créé au moyen d'un antisolvant FSC dans une zone fermée. Les particules noyaux sont mises en contact dans cette zone à des conditions quasi-critiques ou supercritiques avec une dispersion fluide contenant un dispersant et, conjointement, une substance précipitable. L'antisolvant épuise de dispersant et ladite substance est précipitée sur les particules fluidisées.

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