A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/16 (2006.01) B01D 9/04 (2006.01) B01D 21/26 (2006.01) B01D 61/24 (2006.01) B01J 19/10 (2006.01) A61M 1/02 (2006.01)
Patent
CA 2343826
A method and system (10) for selectively removing one component of a material thereby concentrating other components of the material are disclosed. The material is cooled to below the melting temperature of the material to form a supercooled liquid phase with heat transfer plate with cooling channels (20). Ultrasonic energy from ultrasonic drivers (42) is applied to the material to form solid phase crystals of the component to be removed. These crystals are removed to leave the concentrated product. The ultrasonic energy prevents the growth of dendrites on the crystals, resulting in the formation and removal of small crystals of the component to be removed without damage to or removal of the remaining components. Methods and apparatuses for cryoprecipitation and chromatography are also disclosed.
L'invention concerne un procédé et un système (10) pour enlever de manière sélective un composant d'une substance et augmenter ainsi la concentration des autres composants dans ladite substance. La substance est refroidie jusqu'à une température inférieure à celle de fusion de la substance pour former une phase liquide en surfusion sur une plaque de transfert de chaleur avec des canaux de refroidissement (20). On applique à la substance de l'énergie ultrasonique provenant de conducteurs d'ultrasons (42) pour former des cristaux en phase solide du composant à enlever. Ces cristaux sont enlevés, et l'on obtient un produit concentré. L'énergie ultrasonique empêche la croissance de dendrites sur les cristaux et permet la formation de petits cristaux du composant, qui sont enlevés sans endommager ou enlever les composants restants. L'invention concerne aussi des procédés de cryoprécipitation et de chromatographie.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Purdum Howard E.
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