Methods and biomarkers for diagnosing and monitoring...

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G01R 33/465 (2006.01)

Patent

CA 2626490

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1 ,: VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

L'invention concerne des procédés de diagnostic et de surveillance d'un trouble psychotique chez un sujet, qui comportent les étapes consistant à: fournir un échantillon biologique test provenant du sujet, soumettre l'échantillon biologique à une analyse spectrale afin de produire un ou plusieurs spectre(s), et comparer le(s) spectre(s) à un ou à plusieurs spectre(s) témoin(s). L'invention concerne aussi des procédés permettant de diagnostiquer ou de surveiller des troubles psychotiques tels que des troubles schizophréniques ou bipolaires, et qui comportent les étapes consistant à: mesurer le taux d'un ou de plusieurs biomarqueur(s) présent(s) dans un échantillon biologique prélevé sur un sujet testé, lesdits biomarqueurs étant sélectionné(s) dans le groupe constitué par la transthyrétine, l'ApoA1, les VLDL, les LDL et des espèces aromatiques telles que les protéines plasmatiques. L'invention concerne aussi des capteurs, des biocapteurs, des groupes d'analytes multiples, des réseaux, des dosages et des trousses pour mettre en oeuvre les procédés de l'invention.

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