Methods and cells for detecting modulators of rgs proteins

Details Methods and cells for detecting modulators of rgs proteins Methods and cells for detecting modulators of rgs proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2430475

This application describes novel cells that respond to a pheromone comrising a heterologous nucleic acid encoding a reporter operably linked to a pheromone- responsive promoter. The cells may further comprises a heterologous nucleic acid encoding an RGS protein. Also described are methods involving the use of these cells for detecting the ability of a test sample to alter RGS protein- mediated reporter gene expression.

L'invention concerne de nouvelles cellules sensibles à une phéromone comprenant un acide nucléique hétérologue codant pour un rapporteur lié à un promoteur sensible aux phéromones. Lesdites cellules peuvent également comprendre un acide nucléique hétérologue codant pour une protéine RGS. L'invention concerne également des méthodes consistant à utiliser ces cellules pour détecter la capacité d'un échantillon d'essai à modifier l'expression du gène rapporteur associée à une protéine RGS.

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