A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2491547
The invention provides novel methods and compositions for modulating type I muscle formation through modulation of PGC-1.alpha. activity or expression. Also provided are methods for identifying compounds that modulate type I muscle formation through modulation of PGC-1.alpha. activity or expression. Further provided are methods for treating disorders associated with type I and/or type II muscle formation, as well as transgenic animals expressing PGC- 1.alpha. in muscle.
Cette invention concerne des méthodes et des compositions nouvelles permettant de moduler la formation de fibres musculaires de type I par modulation de l'activité ou de l'expression de PGC-1?. Sont également décrites des méthodes d'identification de composants qui modulent la formation de fibres musculaires de type I par la modulation de l'activité ou de l'expression de PGC-1?. L'invention concerne en outre des méthodes de traitement de troubles associés à la formation de fibres musculaires de type I et/ou de type II, ainsi que des animaux transgéniques exprimant PGC-1? au niveau des muscles.
Lin Jiandie
Spiegelman Bruce M.
Borden Ladner Gervais Llp
Dana-Farber Cancer Institute Inc.
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