A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/737 (2006.01) A61K 31/715 (2006.01) A61K 31/727 (2006.01) A61K 31/728 (2006.01) A61K 31/734 (2006.01) A61K 31/738 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) A61K 47/48 (2006.01) A61L 27/00 (2006.01) A61L 27/20 (2006.01) A61L 27/34 (2006.01) A61L 29/00 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) A61L 25/00 (1990.01)
Patent
CA 2110291
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus, the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10 % by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.
Coker George T. III
Frederickson Robert C.a.
Harel Adrian
Roufa Dikla
Gliatech Inc.
Osler Hoskin & Harcourt Llp
Wright Medical Technology Inc.
LandOfFree
Methods and compositions based on inhibition of cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions based on inhibition of cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions based on inhibition of cell... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1505927